Welcome to the EPIGEN MeQTL Database

 

Multiple studies have shown that genetic effects can have strong impacts on DNA methylation levels. Methylation quantitative trait loci (meQTLs) are genetic loci at which genetic variation is associated with variation in DNA methylation at a specific CpG site.

The EPIGEN MeQTL Database compiles results from multiple meQTL studies conducted by the Epigenomics Research Group at the Department of Twin Research at King’s College London, under the leadership of Dr Jordana Bell. Details of the available databases are outlined below.

You can explore the CpGs and meQTL SNPs in their genomic context in the Visualisation tab.

MeQTL summary


EPIC Database

The EPIC DB reports the results of a meQTL analysis at 724,499 CpGs profiled with the Illumina Infinium MethylationEPIC array in 2,358 blood samples from three UK cohorts (Villicaña et al. (2023). Genome Biology 24, 176.)

The tables available for display can include either 1) a top SNP per CpG or 2) all meQTLs after LD-clumping. You can access the complete, unclumped cis and trans results at a FDR 5% on Zenodo at DOI 10.5281/zenodo.8047777.

MeQTL summary

Skin Database

The Skin DB reports the results of meQTL analysis in whole-skin tissue samples from up to 394 twins, profiled using the Infinium HumanMethylation450 BeadChip (Shore et al., under review).

The table displays the conditionally independent CpG-meQTL associations identified using the cojo --slct method. You can download the complete cis results at a FDR 5% level at the bottom of the tab.


Maintained by [Sergio Villicaña](mailto:sergio.villicana_munoz@kcl.ac.uk)
Department of Twin Research & Genetic Epidemiology
[Jordana Bell Lab](https://www.kcl.ac.uk/people/jordana-bell)